Read our publications and view the posters and presentations we have shared at scientific meetings. For inquiries regarding our publications, please email us.

Most Recent Publications
See the drop down menu under Publications for yearly archives.

An Inducible Luminescent System to Explore Parkinson’s Disease-Associated Genes

August 2024

Anelya Gandy et al.

https://doi.org/10.3390/ijms25179493

Generation of human iPSC-derived phrenic-like motor neurons to model respiratory motor neuron degeneration in ALS

February 2024

Thiry L. et al.

https://doi.org/10.1002/glia.24524

The 37TrillionCells initiative for improving global healthcare via cell-based interception and precision medicine: focus on neurodegenerative diseases

April 2024

Coulombe B. et al.

https://doi.org/10.1186/s13041-024-01088-4

MerTK is a mediator of alpha-synuclein fibril uptake by human microglia

September 2023

Dorion M. et al.

https://doi.org/10.1093/brain/awad298

The next generation of tools and technologies for studying human neurons in a dish

April 2023

Durcan TM, Axtman AD.

DOI: 10.3389/fncel.2023.1196543

Compressive molding of engineered tissues via thermoresponsive hydrogel devices

March 2023

Cassel de Camps C, Mok S, Ashby E, Li C, Lépine P, Durcan TM, Moraes C.

DOI: 10.1039/d3lc00007a

Image that represents the paper: Loss of C9orf72 perturbs the Ran-GTPase gradient and generates compositionally diverse cytoplasmic Importin β-1 granules in motor and cortical neurons in vivo

Loss of C9orf72 perturbs the Ran-GTPase gradient and generates compositionally diverse cytoplasmic Importin β-1 granules in motor and cortical neurons in vivo

February 2023

Philip McGoldrick et al.

DOI: 10.1101/2021.10.20.465148

CelltypeR: A flow cytometry pipeline to characterize single cells from brain organoids

July 2024

Rhalena A. Thomas et al.

https://doi.org/10.1016/j.isci.2024.110613

An adapted protocol to derive microglia from stem cells and its application in the study of CSF1R-related disorders

April 2024

Dorion M. et al.

https://doi.org/10.1186/s13024-024-00723-x

The Use of a SOX10 Reporter Towards Ameliorating Oligodendrocyte Lineage Differentiation from Human Induced Pluripotent Stem Cells

March 2024

Piscopo V. et al.

https://doi.org/10.1002/glia.24524

Transcriptional dysregulation and impaired neuronal activity in FMR1 knock-out and Fragile X patients’ iPSC-derived models

August 2023

Dorion M. et al.

https://doi.org/10.1093/brain/awad298

Image that represents the paper: Excitatory neuron-specific suppression of the integrated stress response pathway contributes to autism-related phenotypes in a mouse model of fragile X syndrome

Excitatory neuron-specific suppression of the integrated stress response pathway contributes to autism-related phenotypes in a mouse model of fragile X syndrome

April 2023

Hooshmandi M et al.

DOI: 10.1101/2023.04.24.538123

Structure-based design and characterization of Parkin-activating mutations

March 2023

Micheal Stevens et al.

DOI: 10.26508/lsa.202201419

An Optimized Workflow to Generate and Characterize iPSC-Derived Motor Neuron (MN) Spheroids

February 2023

Maria Jose Castellanos-Montiel et al.

DOI: 10.3390/cells12040545

Early nuclear phenotypes and reactive transformation in human iPSC-derived astrocytes from ALS patients with SOD1 mutations

August 2024

Vincent Soubannier et al.

https://doi.org/10.1002/glia.24598

Illumination of understudied ciliary kinases

March 2024

Flax R. et al.

https://doi.org/10.1186/s13041-024-01088-4

Homozygous ALS-linked mutations in TARDBP/TDP-43 lead to hypoactivity and synaptic abnormalities in human iPSC-derived motor neurons

March 2024

Lépine S. et al.

https://doi.org/10.1016/j.isci.2024.109166

Image that represents the paper: Fast 3D Optoacoustic Mesoscopy of Neuromelanin Through Entire Human Midbrain Organoids at Single-Cell Resolution

Fast 3D Optoacoustic Mesoscopy of Neuromelanin Through Entire Human Midbrain Organoids at Single-Cell Resolution

July 2023

Englert L. et al.

DOI: 10.1002/lpor.202300443

α-synuclein preformed fibrils bind to β-neurexins and impair β-neurexin-mediated presynaptic organization

April 2023

Benjamin Feller et al.

DOI: 10.1101/2023.01.28.526024

Visualization of α-synuclein trafficking via nanogold labeling and electron microscopy

February 2023

Armin Bayati et al.

DOI: 10.1016/j.xpro.2023.102113

Image that represents the paper: Systematic comparison of culture media uncovers phenotypic shift of primary human microglia defined by reduced reliance to CSF1R signaling

Systematic comparison of culture media uncovers phenotypic shift of primary human microglia defined by reduced reliance to CSF1R signaling

January 2023

Marie-France Dorion et al.

DOI: 10.1002/glia.24338

Posters

Development of in vitro ALS discovery and
translational assays with patient-derived cells

View PDF

Mathilde Chaineau, Vincent Soubannier, Lale Gursu, Anna Krystina Franco-Flores, Ghazal Haghi, María José Castellanos-Montiel
Sarah Lépine, Carol X-Q Chen, Valerio Piscopo, Narges Abdian and Thomas M. Durcan

Studying the effects of NF subunit abnormalities in neuromuscular junction morphology and function

View PDF

María José Castellanos-Montiel, Anna Krystina Franco-Flores, Sarah Lépine, Lale Gursu, Ghazal Haghi, Mathilde Chaineau, Carol X-Q Chen, Narges Abdian, Eric Deneault, Michael Nicouleau, Thomas M. Durcan

Screening for compounds that reduce alpha synuclein fibril load in iPSC-derived neuronal cells

View PDF

Andrea I. Krahn, Wolfgang E. Reintsch, Chanshuai Han, Emmanuelle Nguyen-Renou, Carol X.-Q. Chen, Wen Luo, Edward A. Fon, Thomas M. Durcan

Nuclear phenotypes and astrogliosis in astrocytes derived from ALS SOD1(A4V)-mutated iPSCs

View PDF

Vincent Soubannier, Mathilde Chaineau, Lale Gursu, Sarah Lepine, Guy Rouleau, Thomas M. Durcan and Stefano Stifani

Image that represents the poster: Single-cell RNA sequence analysis of post-mortem midbrain tissue reveals altered glial cell function in Parkinson's disease

Single-cell RNA sequence analysis of post-mortem midbrain tissue reveals altered glial cell function in Parkinson's disease

View PDF

Indra Roy, Rhalena A. Thomas, Thomas M. Durcan

Transcriptome-based in silico screening in human motor neurons with ALS-associated mutations in TARDBP/TDP-43

View PDF

Sarah Lépine, Gilles Maussion, Alexandria Schneider, Angela Nauleau-Javaudin, Georgina Jiménez Ambriz, Dan Spiegelman, María José Castellanos-Montiel, Narges Abdian, Anna K.Franco-Flores, Ghazal Haghi, Lale Gursu, Mathilde Chaineau, and Thomas M. Durcan

The Mer tyrosine kinase mediates the internalization of alpha-synuclein fibrils by human microglia

View PDF

Marie-France Dorion, Konstantin Senkevich, Moein Yaqubi, Wen Luo, Amber Wallis, Irina Shlaifer, Jack P. Antel, Ziv Gan-Or, Tim Bartel, Thomas M. Durvan, Luke M. Healy

Presentations

Image of Thomas Durcan presentation about iPSC

Presentations

Read our publications and view the posters and presentations we have shared at scientific meetings. For inquiries regarding our publications, please email us.

Most Recent Publications See the drop down menu under Publications for yearly archives.

An Inducible Luminescent System to Explore Parkinson’s Disease-Associated Genes

Generation of human iPSC-derived phrenic-like motor neurons to model respiratory motor neuron degeneration in ALS

The 37TrillionCells initiative for improving global healthcare via cell-based interception and precision medicine: focus on neurodegenerative diseases

MerTK is a mediator of alpha-synuclein fibril uptake by human microglia

The next generation of tools and technologies for studying human neurons in a dish

Compressive molding of engineered tissues via thermoresponsive hydrogel devices

Loss of C9orf72 perturbs the Ran-GTPase gradient and generates compositionally diverse cytoplasmic Importin β-1 granules in motor and cortical neurons in vivo

CelltypeR: A flow cytometry pipeline to characterize single cells from brain organoids

An adapted protocol to derive microglia from stem cells and its application in the study of CSF1R-related disorders

The Use of a SOX10 Reporter Towards Ameliorating Oligodendrocyte Lineage Differentiation from Human Induced Pluripotent Stem Cells

Transcriptional dysregulation and impaired neuronal activity in FMR1 knock-out and Fragile X patients’ iPSC-derived models

Excitatory neuron-specific suppression of the integrated stress response pathway contributes to autism-related phenotypes in a mouse model of fragile X syndrome

Structure-based design and characterization of Parkin-activating mutations

An Optimized Workflow to Generate and Characterize iPSC-Derived Motor Neuron (MN) Spheroids

Early nuclear phenotypes and reactive transformation in human iPSC-derived astrocytes from ALS patients with SOD1 mutations

Illumination of understudied ciliary kinases

Homozygous ALS-linked mutations in TARDBP/TDP-43 lead to hypoactivity and synaptic abnormalities in human iPSC-derived motor neurons

Fast 3D Optoacoustic Mesoscopy of Neuromelanin Through Entire Human Midbrain Organoids at Single-Cell Resolution

α-synuclein preformed fibrils bind to β-neurexins and impair β-neurexin-mediated presynaptic organization

Visualization of α-synuclein trafficking via nanogold labeling and electron microscopy

Systematic comparison of culture media uncovers phenotypic shift of primary human microglia defined by reduced reliance to CSF1R signaling

Posters

Development of in vitro ALS discovery and translational assays with patient-derived cells

Studying the effects of NF subunit abnormalities in neuromuscular junction morphology and function

Screening for compounds that reduce alpha synuclein fibril load in iPSC-derived neuronal cells

Nuclear phenotypes and astrogliosis in astrocytes derived from ALS SOD1(A4V)-mutated iPSCs

Single-cell RNA sequence analysis of post-mortem midbrain tissue reveals altered glial cell function in Parkinson's disease

Transcriptome-based in silico screening in human motor neurons with ALS-associated mutations in TARDBP/TDP-43

The Mer tyrosine kinase mediates the internalization of alpha-synuclein fibrils by human microglia

Presentations

Most Recent Publications
See the drop down menu under Publications for yearly archives.

Development of in vitro ALS discovery and
translational assays with patient-derived cells