Check out preprints we have helped contribute towards.

A genome-wide CRISPR/Cas9 screen identifies genes that regulate the cellular uptake of α-synuclein fibrils by modulating heparan sulfate proteoglycans

September 2023

B. Vanderperre et al.

DOI: https://doi.org/10.1101/2023.09.29.560170

Loss of symmetric cell division of apical neural progenitors drives DENND5A-related developmental and epileptic encephalopathy

January 2024

E. Banks et al.

DOI:https://doi.org/10.1101/2022.08.23.22278845

The functional and pathogenic consequences of fibrinogen on human oligodendroglia

June 2024

G. Blaszczyk et al.

DOI: https://doi.org/10.1101/2024.05.27.596068

Image that represents the pre-print: Scaling of an antibody validation procedure enables quantification of antibody performance in major research applications

Scaling of an antibody validation procedure enables quantification of antibody performance in major research applications

July 2023

Riham Ayoubi, Joel Ryan, Maryam Fotouhi, Walaa Alshafie, Sara Gonzalez Bolivar, Vera Ruiz Moleon, Wolfgang Reintsch, Peter Eckmann, Donovan Worrall, Ian McDowell, Kathleen Southern, Thomas M. Durcan, Claire M. Brown, Anita Bandrowski, Harvinder S. Virk, Aled M Edwards, Peter S McPherson, Carl Laflamme

DOI: 10.1101/2023.06.01.543292

Image that represents the pre-print: Genetic inactivation of the USP19 deubiquitinase regulates a-synuclein ubiquitination and inhibits accumulation of Lewy body like aggregates in mice

Genetic inactivation of the USP19 deubiquitinase regulates a-synuclein ubiquitination and inhibits accumulation of Lewy body like aggregates in mice

December 2022

Lenka Shorova et al.

DOI: 10.1101/2022.12.21.521125

The Parkinson’s disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons

November 2023

Jace Jones-Tabah et al.

DOI: https://doi.org/10.1101/2023.11.11.566693

Secondary deficiency of neuraminidase 1 contributes to CNS pathology in neurological mucopolysaccharidoses via hypersialylation of brain glycoproteins

April 2024

T. Xu et al.

DOI:https://doi.org/10.1101/2024.04.26.587986

Early nuclear phenotypes and reactive transformation in human iPSC

October 2023

TianMeng Xu et al.

DOI: https://doi.org/10.1101/2024.04.26.587986

Image that represents the pre-print: A dual hit of α-synuclein internalization and immune challenge leads to formation and maintenance of Lewy body-like inclusions in human dopaminergic neurons

A dual hit of α-synuclein internalization and immune challenge leads to formation and maintenance of Lewy body-like inclusions in human dopaminergic neurons

May 2023

Armin Bayati, Riham Ayoubi, Cornelia E. Zorca, Adriana Aguila, Chanshuai Han, Emily Banks, Emmanuelle Nguyen-Renou, Wen Luo, Irina Shlaifer, Esther Del Cid-Pellitero, Moein Yaqubi, Edward A. Fon, Jo Anne Stratton, Thomas M. Durcan, Patrick

Nahirney, Peter S. McPherson

DOI: 10.1101/2023.05.29.542776

Image that represents the pre-print: CelltypeR: A framework to identify and characterize cell types in human midbrain organoids using flow cytometry

CelltypeR: A framework to identify and characterize cell types in human midbrain organoids using flow cytometry

November 2022

Rhalena A. Thomas et al.

DOI: 10.1101/2022.11.11.516066

Transcriptome-based screening in TARDBP/TDP-43 knock-in motor neurons identifies the NEDD8-activating enzyme inhibitor MLN4924

January 2024

Sarah Lépine et al.

DOI: https://doi.org/10.1101/2024.01.30.578100

Sex-focused analyses of M83 A53T hemizygous mouse model with recombinant human alpha-synuclein preformed fibril injection identifies female resilience to disease progression: A combined magnetic resonance imaging and behavioural study

May 2024

S. Tullo et al.

DOI:https://doi.org/10.1101/2022.08.23.22278845

KCC2 as a novel biomarker and therapeutic target for motoneuron degenerative disease

August 2023

C. Sahara Khademullah, Julien Bourbonnais, Mathilde M. Chaineau, María José Castellanos-Montiel, Iason Keramidis, Alexandra Legault, Marie-Ève Paquet, Agessandro Abrahao, Lorne Zinman, Janice Robertson, Thomas M. Durcan, Melanie A. Woodin, Antoine G. Godin, Yves De Koninck

DOI: https://doi.org/10.1101/2023.08.24.554410

Image that represents the pre-print: Homozygous ALS-linked mutations in TARDBP/TDP-43 lead to progressive synaptic dysfunction in human iPSC-derived motor neurons

Homozygous ALS-linked mutations in TARDBP/TDP-43 lead to progressive synaptic dysfunction in human iPSC-derived motor neurons

March 2023

Sarah Lépine et al.

DOI: 10.1101/2023.03.22.533562

Image that represents the pre-print: Presymptomatic neuroanatomical and cognitive biomarkers of alpha-synuclein propagation in a mouse model of synucleinopathy

Presymptomatic neuroanatomical and cognitive biomarkers of alpha-synuclein propagation in a mouse model of synucleinopathy

October 2022

Stephanie Tullo et al.

DOI: 10.1101/2022.10.12.511820