Read our 2023-2024 publications below.

Original Papers
(scroll down to see posters)

An Inducible Luminescent System to Explore Parkinson’s Disease-Associated Genes

August 2024

Anelya Gandy et al.

https://doi.org/10.3390/ijms25179493

Generation of human iPSC-derived phrenic-like motor neurons to model respiratory motor neuron degeneration in ALS

February 2024

Thiry L. et al.

https://doi.org/10.1002/glia.24524

The 37TrillionCells initiative for improving global healthcare via cell-based interception and precision medicine: focus on neurodegenerative diseases

April 2024

Coulombe B. et al.

https://doi.org/10.1186/s13041-024-01088-4

MerTK is a mediator of alpha-synuclein fibril uptake by human microglia

September 2023

Dorion M. et al.

https://doi.org/10.1093/brain/awad298

The next generation of tools and technologies for studying human neurons in a dish

April 2023

Durcan TM, Axtman AD.

DOI: 10.3389/fncel.2023.1196543

Compressive molding of engineered tissues via thermoresponsive hydrogel devices

March 2023

Cassel de Camps C, Mok S, Ashby E, Li C, Lépine P, Durcan TM, Moraes C.

DOI: 10.1039/d3lc00007a

Image that represents the paper: Loss of C9orf72 perturbs the Ran-GTPase gradient and generates compositionally diverse cytoplasmic Importin β-1 granules in motor and cortical neurons in vivo

Loss of C9orf72 perturbs the Ran-GTPase gradient and generates compositionally diverse cytoplasmic Importin β-1 granules in motor and cortical neurons in vivo

February 2023

Philip McGoldrick et al.

DOI: 10.1101/2021.10.20.465148

CelltypeR: A flow cytometry pipeline to characterize single cells from brain organoids

July 2024

Rhalena A. Thomas et al.

https://doi.org/10.1016/j.isci.2024.110613

An adapted protocol to derive microglia from stem cells and its application in the study of CSF1R-related disorders

April 2024

Dorion M. et al.

https://doi.org/10.1186/s13024-024-00723-x

The Use of a SOX10 Reporter Towards Ameliorating Oligodendrocyte Lineage Differentiation from Human Induced Pluripotent Stem Cells

March 2024

Piscopo V. et al.

https://doi.org/10.1002/glia.24524

Transcriptional dysregulation and impaired neuronal activity in FMR1 knock-out and Fragile X patients’ iPSC-derived models

August 2023

Dorion M. et al.

https://doi.org/10.1093/brain/awad298

Image that represents the paper: Excitatory neuron-specific suppression of the integrated stress response pathway contributes to autism-related phenotypes in a mouse model of fragile X syndrome

Excitatory neuron-specific suppression of the integrated stress response pathway contributes to autism-related phenotypes in a mouse model of fragile X syndrome

April 2023

Hooshmandi M et al.

DOI: 10.1101/2023.04.24.538123

Structure-based design and characterization of Parkin-activating mutations

March 2023

Micheal Stevens et al.

DOI: 10.26508/lsa.202201419

An Optimized Workflow to Generate and Characterize iPSC-Derived Motor Neuron (MN) Spheroids

February 2023

Maria Jose Castellanos-Montiel et al.

DOI: 10.3390/cells12040545

Early nuclear phenotypes and reactive transformation in human iPSC-derived astrocytes from ALS patients with SOD1 mutations

August 2024

Vincent Soubannier et al.

https://doi.org/10.1002/glia.24598

Illumination of understudied ciliary kinases

March 2024

Flax R. et al.

https://doi.org/10.1186/s13041-024-01088-4

Homozygous ALS-linked mutations in TARDBP/TDP-43 lead to hypoactivity and synaptic abnormalities in human iPSC-derived motor neurons

March 2024

Lépine S. et al.

https://doi.org/10.1016/j.isci.2024.109166

Image that represents the paper: Fast 3D Optoacoustic Mesoscopy of Neuromelanin Through Entire Human Midbrain Organoids at Single-Cell Resolution

Fast 3D Optoacoustic Mesoscopy of Neuromelanin Through Entire Human Midbrain Organoids at Single-Cell Resolution

July 2023

Englert L. et al.

DOI: 10.1002/lpor.202300443

α-synuclein preformed fibrils bind to β-neurexins and impair β-neurexin-mediated presynaptic organization

April 2023

Benjamin Feller et al.

DOI: 10.1101/2023.01.28.526024

Visualization of α-synuclein trafficking via nanogold labeling and electron microscopy

February 2023

Armin Bayati et al.

DOI: 10.1016/j.xpro.2023.102113

Image that represents the paper: Systematic comparison of culture media uncovers phenotypic shift of primary human microglia defined by reduced reliance to CSF1R signaling

Systematic comparison of culture media uncovers phenotypic shift of primary human microglia defined by reduced reliance to CSF1R signaling

January 2023

Marie-France Dorion et al.

DOI: 10.1002/glia.24338

Posters

Development of an Open Science Collection of Patient-Derived iPSCs
for Studying Disease Mechanisms in Neurodegenerative Diseases

View PDF

Carol XQ Chen, Taylor M Goldsmith, Nicolas Ferry, Narges Abdian, Zhipeng You, Michaël Nicouleau,
Marie-Noëlle Boivin, Lydiane Gaborieau, Peng Wang, Kevin LaFleur, Sophiya Enjambre, Jason Karamchandani,
Thomas M. Durcan

Screening for compounds that reduce alpha synuclein fibril load in iPSC-derived neuronal cells

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Andrea I. Krahn, Wolfgang E. Reintsch, Chanshuai Han, Emmanuelle Nguyen-Renou, Carol X.-Q. Chen, Wen Luo, Edward A. Fon, Thomas M. Durcan

Image that represents the poster: Single-cell RNA sequence analysis of post-mortem midbrain tissue reveals altered glial cell function in Parkinson's disease

Single-cell RNA sequence analysis of post-mortem midbrain tissue reveals altered glial cell function in Parkinson's disease

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Indra Roy, Rhalena A. Thomas, Thomas M. Durcan

The Mer tyrosine kinase mediates the internalization of alpha-synuclein fibrils by human microglia

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Marie-France Dorion, Konstantin Senkevich, Moein Yaqubi, Wen Luo, Amber Wallis, Irina Shlaifer, Jack P. Antel, Ziv Gan-Or, Tim Bartel, Thomas M. Durvan, Luke M. Healy

Read our 2023-2024 publications below.

Original Papers (scroll down to see posters)

An Inducible Luminescent System to Explore Parkinson’s Disease-Associated Genes

Generation of human iPSC-derived phrenic-like motor neurons to model respiratory motor neuron degeneration in ALS

The 37TrillionCells initiative for improving global healthcare via cell-based interception and precision medicine: focus on neurodegenerative diseases

MerTK is a mediator of alpha-synuclein fibril uptake by human microglia

The next generation of tools and technologies for studying human neurons in a dish

Compressive molding of engineered tissues via thermoresponsive hydrogel devices

Loss of C9orf72 perturbs the Ran-GTPase gradient and generates compositionally diverse cytoplasmic Importin β-1 granules in motor and cortical neurons in vivo

CelltypeR: A flow cytometry pipeline to characterize single cells from brain organoids

An adapted protocol to derive microglia from stem cells and its application in the study of CSF1R-related disorders

The Use of a SOX10 Reporter Towards Ameliorating Oligodendrocyte Lineage Differentiation from Human Induced Pluripotent Stem Cells

Transcriptional dysregulation and impaired neuronal activity in FMR1 knock-out and Fragile X patients’ iPSC-derived models

Excitatory neuron-specific suppression of the integrated stress response pathway contributes to autism-related phenotypes in a mouse model of fragile X syndrome

Structure-based design and characterization of Parkin-activating mutations

An Optimized Workflow to Generate and Characterize iPSC-Derived Motor Neuron (MN) Spheroids

Early nuclear phenotypes and reactive transformation in human iPSC-derived astrocytes from ALS patients with SOD1 mutations

Illumination of understudied ciliary kinases

Homozygous ALS-linked mutations in TARDBP/TDP-43 lead to hypoactivity and synaptic abnormalities in human iPSC-derived motor neurons

Fast 3D Optoacoustic Mesoscopy of Neuromelanin Through Entire Human Midbrain Organoids at Single-Cell Resolution

α-synuclein preformed fibrils bind to β-neurexins and impair β-neurexin-mediated presynaptic organization

Visualization of α-synuclein trafficking via nanogold labeling and electron microscopy

Systematic comparison of culture media uncovers phenotypic shift of primary human microglia defined by reduced reliance to CSF1R signaling

Posters

Development of an Open Science Collection of Patient-Derived iPSCs for Studying Disease Mechanisms in Neurodegenerative Diseases

Screening for compounds that reduce alpha synuclein fibril load in iPSC-derived neuronal cells

Single-cell RNA sequence analysis of post-mortem midbrain tissue reveals altered glial cell function in Parkinson's disease

The Mer tyrosine kinase mediates the internalization of alpha-synuclein fibrils by human microglia

Original Papers
(scroll down to see posters)

Development of an Open Science Collection of Patient-Derived iPSCs
for Studying Disease Mechanisms in Neurodegenerative Diseases