Anchor 1

Read our 2021-2022 publications below.

Original Papers
(scroll down to see reviews)

Image that represents the paper: The identification of potent and selective antibodies for Serine/threonine-protein kinase TBK1, for use in immunoblot, immunofluorescence and immunoprecipitation

The identification of potent and selective antibodies for Serine/threonine-protein kinase TBK1, for use in immunoblot, immunofluorescence and immunoprecipitation

June 2022

Walaa Alshafie et al.

DOI: 10.1101/2022.06.03.494699

Image that represents the paper: Generation of homozygous PRKN, PINK1 and double PINK1/PRKN knockout cell lines from healthy induced pluripotent stem cells using CRISPR/Cas9 editing

Generation of homozygous PRKN, PINK1 and double PINK1/PRKN knockout cell lines from healthy induced pluripotent stem cells using CRISPR/Cas9 editing

May 2022

Carol X.-Q. Chen et al.

DOI: 10.1016/j.scr.2022.102806

FOXG1 dose tunes cell proliferation dynamics in human forebrain progenitor cells

February 2022

Nuwan C. Hettige et al.

DOI: 10.1016/j.stemcr.2022.01.010

Auto-qPCR: A Python-based web app for automated and reproducible analysis of qPCR data

October 2021

Gilles Maussion et al.

DOI: 10.1038/s41598-021-99727-6

Selective localization of Mfn2 near PINK1 enable its preferential ubiquitination by Parkin on mitochondria

January 2022

Marta Vranas et al.

DOI: 10.1098/rsob.210255

Identification of amyloid beta in small extracellular vesicles via Raman spectroscopy

June 2021

Meruyert Imanbekova et al.

DOI: 10.1039/d1na00330e

Generation of human midbrain organoids from induced pluripotent stem cells

February 2021

Nguyen-Vi Mohamed et al.

DOI: 10.12688/mniopenres.12816.2

Image that represents the paper: Generation of patient-derived pluripotent stem cell-lines and CRISPR modified isogenic controls with mutations in the Parkinson’s associated GBA gene

Generation of patient-derived pluripotent stem cell-lines and CRISPR modified isogenic controls with mutations in the Parkinson’s associated GBA gene

October 2022

Carol X.-Q. Chen et al.

DOI: 10.1016/j.scr.2022.102919

Image that represents the paper: A light-inducible protein clustering system for in vivo analysis of α-synuclein aggregation in Parkinson disease

A light-inducible protein clustering system for in vivo analysis of α-synuclein aggregation in Parkinson disease

March 2022

Morgan Bérard et al.

DOI: 10.1371/journal.pbio.3001578

Image that represents the paper: Rapid Generation of Ventral Spinal Cord-like Astrocytes from Human iPSCs for Modeling Non-Cell Autonomous Mechanisms of Lower Motor Neuron Disease

Rapid Generation of Ventral Spinal Cord-like Astrocytes from Human iPSCs for Modeling Non-Cell Autonomous Mechanisms of Lower Motor Neuron Disease

January 2022

Vincent Soubannier et al.

DOI: 10.3390/cells11030399

Midbrain organoids with an SNCA gene triplication model key features of synucleinopathy

September 2021

Nguyen-Vi Mohamed et al.

DOI: 10.1101/2021.04.12.439480

A Multistep Workflow to Evaluate Newly Generated iPSCs and Their Ability to Generate Different Cell Types

July 2021

Carol X.-Q. Chen et al.

DOI: 10.3390/mps4030050

Image that represents the paper: Optogenetic-Mediated Spatiotemporal Control of α-Synuclein Aggregation Mimics Lewy Body Formation and Triggers Neurodegeneration

Optogenetic-Mediated Spatiotemporal Control of α-Synuclein Aggregation Mimics Lewy Body Formation and Triggers Neurodegeneration

May 2021

Morgan Berard et al.

DOI: 10.2139/ssrn.3854707

Development of an α-synuclein knockdown peptide and evaluation of its efficacy in Parkinson's disease models

February 2021

Jack Wuyang Jin et al.

DOI: 10.1038/s42003-021-01746-6

Rapid macropinocytic transfer of α-synuclein to lysosomes

July 2022

Armin Bayati et al.

DOI: 10.1016/j.celrep.2022.111102

Image that represents the paper: An Approach to Measuring Protein Turnover in Human Induced Pluripotent Stem Cell Organoids by Mass Spectrometry

An Approach to Measuring Protein Turnover in Human Induced Pluripotent Stem Cell Organoids by Mass Spectrometry

March 2022

Jing Dong et al.

DOI: 10.1016/j.ymeth.2022.03.011

Hydrogel Mechanics Influence the Growth and Development of Embedded Brain Organoids

January 2022

Camille Cassel de Camps et al.

DOI: 10.1021/acsabm.1c01047

Image that represents the paper: A streamlined CRISPR workflow to introduce mutations and generate isogenic iPSCs for modeling amyotrophic lateral sclerosis.

A streamlined CRISPR workflow to introduce mutations and generate isogenic iPSCs for modeling amyotrophic lateral sclerosis

July 2022

Eric Deneault et al.

DOI: 10.1016/j.ymeth.2021.09.002

Microfabricated disk technology: rapid scale up in midbrain organoid generation

July 2021

Nguyen-Vi Mohamed et al.

DOI: 10.1016/j.ymeth.2021.07.008

Image that represents the paper: Pharmacological Inhibition of Brain EGFR Activation By a BBB-penetrating Inhibitor, AZD3759, Attenuates α-synuclein Pathology in a Mouse Model of α-Synuclein Propagation

Pharmacological Inhibition of Brain EGFR Activation By a BBB-penetrating Inhibitor, AZD3759, Attenuates α-synuclein Pathology in a Mouse Model of α-Synuclein Propagation

March 2021

Omid Tavassoly et al.

DOI: 10.1007/s13311-021-01017-6

Reviews

TDP-43 dysregulation and neuromuscular junction disruption in amyotrophic lateral sclerosis

December 2022

Sarah Lépine, Maria José Castellanos-Montiel, Thomas Durcan

DOI: 10.1186/s40035-022-00331-z

Image that represents a review: Post-transcriptional and Post-translational Modifications of Primary Cilia: How to fine tune your neuronal antenna

Post-transcriptional and Post-translational Modifications of Primary Cilia: How to fine tune your neuronal antenna

February 2022

Cecilia Rocha and Panagiotis Prinos

DOI: 10.3389/fncel.2022.809917

Posters

Image that represents the poster: A convolutional neural network distinguishing between Parkinson's disease and healthy cells using microscopy images

A convolutional neural network distinguishing between Parkinson's disease and healthy cells using microscopy images

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Eddie Cai, Wolfgang Reintsch, Chanshaui Han, Sneha Shinde, Roxanne Larivière, Andrea Krahn, Carol X.Q. Chen, Emmanualle Nguyen-Renou, Anna Franco-Flores, Thomas M. Durcan, Edward A. Fon, Rhalena A. Thomas

Standardized QC workflow foranalyzing the quality and differentiation potential of human iPSCs

Carol X-Q. Chen, Narges Abdian, Gilles Maussion, Rhalena A. Thomas, Iveta Demirova, Eddie Cai, Edward A. Fon, Thomas M. Durcan

Read our 2021-2022 publications below.

Original Papers (scroll down to see reviews)

The identification of potent and selective antibodies for Serine/threonine-protein kinase TBK1, for use in immunoblot, immunofluorescence and immunoprecipitation

Generation of homozygous PRKN, PINK1 and double PINK1/PRKN knockout cell lines from healthy induced pluripotent stem cells using CRISPR/Cas9 editing

FOXG1 dose tunes cell proliferation dynamics in human forebrain progenitor cells

Auto-qPCR: A Python-based web app for automated and reproducible analysis of qPCR data

Selective localization of Mfn2 near PINK1 enable its preferential ubiquitination by Parkin on mitochondria

Identification of amyloid beta in small extracellular vesicles via Raman spectroscopy

Generation of human midbrain organoids from induced pluripotent stem cells

Generation of patient-derived pluripotent stem cell-lines and CRISPR modified isogenic controls with mutations in the Parkinson’s associated GBA gene

A light-inducible protein clustering system for in vivo analysis of α-synuclein aggregation in Parkinson disease

Rapid Generation of Ventral Spinal Cord-like Astrocytes from Human iPSCs for Modeling Non-Cell Autonomous Mechanisms of Lower Motor Neuron Disease

Midbrain organoids with an SNCA gene triplication model key features of synucleinopathy

A Multistep Workflow to Evaluate Newly Generated iPSCs and Their Ability to Generate Different Cell Types

Optogenetic-Mediated Spatiotemporal Control of α-Synuclein Aggregation Mimics Lewy Body Formation and Triggers Neurodegeneration

Development of an α-synuclein knockdown peptide and evaluation of its efficacy in Parkinson's disease models

Rapid macropinocytic transfer of α-synuclein to lysosomes

An Approach to Measuring Protein Turnover in Human Induced Pluripotent Stem Cell Organoids by Mass Spectrometry

Hydrogel Mechanics Influence the Growth and Development of Embedded Brain Organoids

A streamlined CRISPR workflow to introduce mutations and generate isogenic iPSCs for modeling amyotrophic lateral sclerosis

Microfabricated disk technology: rapid scale up in midbrain organoid generation

Pharmacological Inhibition of Brain EGFR Activation By a BBB-penetrating Inhibitor, AZD3759, Attenuates α-synuclein Pathology in a Mouse Model of α-Synuclein Propagation

Reviews

TDP-43 dysregulation and neuromuscular junction disruption in amyotrophic lateral sclerosis

Post-transcriptional and Post-translational Modifications of Primary Cilia: How to fine tune your neuronal antenna

Posters

A convolutional neural network distinguishing between Parkinson's disease and healthy cells using microscopy images

Standardized QC workflow foranalyzing the quality and differentiation potential of human iPSCs

Original Papers
(scroll down to see reviews)