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Read our original papers and reviews from 2019 - 2020 below.

Reviews

The Neglected Genes of ALS: Cytoskeletal Dynamics Impact Synaptic Degeneration in ALS

November 2020

María José Castellanos-Montiel, Mathilde Chaineau, Thomas M. Durcan

DOI: 10.3389/fncel.2020.594975

Using Stem Cells to Study the Effects of Cannabis on Neuronal Development

June 2019

Trisha Rao, Thomas M. Durcan

Applying hiPSCs and Biomaterials Towards an Understanding and Treatment of Traumatic Brain Injury

November 2020

María Lacalle-Aurioles, Camille Cassel de Camps, Cornelia E. Zorca, Lenore K. Beitel, and Thomas M. Durcan

DOI: 10.3389/fncel.2020.594304

Image that represents the review: Patient-derived stem cells, another in vitro model, or the missing link toward novel therapies for autism spectrum disorders?

Patient-derived stem cells, another in vitro model, or the missing link toward novel therapies for autism spectrum disorders?

June 2019

Gilles Maussion, Cecilia Rocha, Genevieve Bernard, Lenore K. Beitel, and Thomas M. Durcan

DOI: 10.3389/fped.2019.00225

Image that represents the review: Defining the neural kinome: strategies and opportunities for small molecule drug discovery to target neurodegenerative disorders

Defining the neural kinome: strategies and opportunities for small molecule drug discovery to target neurodegenerative disorders

November 2020

Andrea I. Krahn, Carrow Wells, David H. Drewry, Lenore K. Beitel, Thomas M. Durcan, Alison D. Axtman

DOI: 10.1021/acschemneuro.0c00176

One Step Into the Future: New iPSC Tools to Advance Research in Parkinson's Disease and Neurological Disorders

May 2019

Nguyen-Vi Mohamed, Frédérique Larroquette, Lenore K. Beitel, Edward A. Fon, Thomas M. Durcan

DOI: 10.3233/JPD-181515

Original Papers

Characterization of Human iPSC-derived Spinal Motor Neurons by Single-cell RNA Sequencing

December 2020

Louise Thiry, Regan Hamel, Stefano Pluchino, Thomas M. Durcan, Stefano Stifani

DOI: 10.1016/j.neuroscience.2020.04.041

Characterization of human iPSC-derived astrocytes with potential for disease modelling and drug discovery

July 2020

Vincent Soubannier, Gilles Maussion, Mathilde Chaineau, Veronika Sigutova, Guy Rouleau, Thomas M. Durcan, Stefano Stefani

DOI: 10.1016/j.neulet.2020.135028

Image that represents the paper: Quantitative expansion microscopy for the characterization of the spectrin periodic skeleton of axons using fluorescence microscopy

Quantitative expansion microscopy for the characterization of the spectrin periodic skeleton of axons using fluorescence microscopy

February 2020

Gaby F. Martínez, Nahir G. Gazal, Gonzalo Quassollo, Alan M. Szalai, Esther Del Cid-Pellitero, Thomas M. Durcan, Edward A. Fon, Mariano Bisbal, Fernando D. Stefani, Nicolas Unsain

DOI: 10.1038/s41598-020-59856-w

Image that represents the paper: Implementation of an Antibody characterization procedure and application to the major ALS/FTD disease gene C9ORF72

Implementation of an Antibody characterization procedure and application to the major ALS/FTD disease gene C9ORF72

October 2019

Carl Laflamme, Paul M. McKeever, Rahul Kumar, Julie Schwartz, Mahshad Kolahdouzan, Carol X. Chen, Zhipeng You, Faiza Benaliouad, Opher Gileadi, Heidi M. McBride, Thomas M. Durcan, Aled M. Edwards, Luke M. Healy, Janice Robertson, Peter S. McPherson

DOI: 10.7554/eLife.48363

Nanotherapeutic Modulation of Human Neural Cells and Glioblastoma in Organoids and Monocultures

November 2020

Issan Zhang, Paula Lépine, Chanshuai Han, María Lacalle-Aurioles, Carol X.-Q. Chen, Rainer Haag, Thomas M. Durcan, and Dusica Maysinger

DOI: 10.3390/cells9112434

Image that represents the paper: Stimulation of L-type calcium channels increases tyrosine hydroxylase and dopamine in ventral midbrain cells induced from somatic cells

Stimulation of L-type calcium channels increases tyrosine hydroxylase and dopamine in ventral midbrain cells induced from somatic cells

June 2020

Malvin Jefri, Scott Bell, Huashan Peng, Nuwan Hettige, Gilles Maussion, Vincent Soubannier, Hanrong Wu, Heika Silveira, Jean-Francois Theroux, Luc Moquin, Xin Zhang, Zahia Aouabed, Jeyashree Krishnan, Liam A. O'Leary, Lilit Antonyan, Ying Zhang, Vincent McCarty, Naguib Mechawar, Alain Gratton, Andreas Schuppert, Thomas M. Durcan, Edward A. Fon, Carl Ernst

DOI: 10.1002/sctm.18-0180

The Quebec Parkinson Network: A researcher-patient matching platform and multimodal biorepository

January 2020

Ziv Gan-Or et al.

DOI: 10.3233/JPD-191775

Image that represents the paper: Beneficial effects of cysteamine in Thy1-α-Syn mice and induced pluripotent stem cells with a SNCA gene triplication

Beneficial effects of cysteamine in Thy1-α-Syn mice and induced pluripotent stem cells with a SNCA gene triplication

November 2020

Alberto Siddu, Linda Suzanne David, Nadine Lauinger, Xiuqing Chen, Martine Saint-Pierre, Melanie Alpaugh, Thomas M. Durcan, Francesca Cicchetti

DOI: 10.1016/j.nbd.2020.105042

Image that represents the paper: TNF Receptor-associated Factor 6 Interacts with ALS-linked Misfolded Superoxide Dismutase 1 and Promotes Aggregation

TNF Receptor-associated Factor 6 Interacts with ALS-linked Misfolded Superoxide Dismutase 1 and Promotes Aggregation

March 2020

Sabrina Semmler, Myriam Gagné, Pranav Garg, Sarah R. Pickles, Charlotte Baudouin, Emeline Hamon-Keromen, Laurie Destroismaisons, Yousra Khalfallah, Mathilde Chaineau, Elise Caron, Andrew N. Bayne, Jean-François Trempe, Neil R. Cashman, Alexandra T. Star, Arsalan S. Haqqani, Thomas M. Durcan, Elizabeth M. Meiering, Janice Robertson, Nathalie Grandvaux, Steven S. Plotkin, Heidi M. McBride, Christine Vande Velde

DOI: 10.1074/jbc.RA119.011215

Bcl-2-associated athanogene 5 (BAG5) regulates Parkin-dependent mitophagy and cell death

December 2019

Mitchell L. De Snoo, Erik L. Friesen, Yu Tong Zhang, Rebecca Earnshaw, Geneviève Dorval, Minesh Kapadia, Darren M. O'Hara, Victoria Agapova, Hien Chau, Ornella Pellerito, Matthew Y. Tang, Xinzhu Wang, Gerold Schmitt-Ulms, Thomas M. Durcan, Edward A .Fon, Lorraine V. Kalia, Suneil K. Kalia

DOI: 10.1038/s41419-019-2132-x

Posters

Characterization of the activity-dependent development of iPSC-derived neurons from Fragile X patients

Gilles Maussion, Cecilia Rocha, Vincent Soubannier, Thomas M. Durcan

Image that represents the poster: Quantitative characterization of variability in cortical neurons between healthy human induced pluripotent stem cell lines

Quantitative characterization of variability in cortical neurons between healthy human induced pluripotent stem cell lines

Carol X-Q. Chen, Narges Abdian, Rhalena A. Thomas, Eddie Cai, Edward A. Fon, Thomas M. Durcan, Gracia Gu